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Black Cats boss Roy Keane is facing an injury crisis, with illness striking down some members of his squad.
Dean Whitehead (hamstring) and Nyron Nosworthy (abdominal) are likely to miss out, but Stanislav Varga (suspension), Chris Brown (ankle) and Ben Alnwick (shoulder) are available for the Wearsiders.
The Hatters have Dean Morgan back from a hip injury, but striker Sam Parkin (ankle) and utility-man Paul Underwood (infection) are out of contention.
Defender Sol Davis remains sidelined, as he recovers from suffering a stroke last month, while youngster Calvin Andrew (knee) is a long-term injury casualty.