Frédéric Kanouté faces a race against time to be fit for the derby encounter against Real Betis as he continues to struggle with a groin injury.
The Malian striker is being carefully watched by the Sevilla coaching staff during training and they are prepared to pull him out if he shows any sign of aggravating the problem.
"We are worried about him," confirmed Ramos. "We are having to weigh up what to do about him.
"The main thing is to ensure that he returns to 100 per cent fitness because we do not want him to play at anything less."
After playing in the Copa Del Rey first leg meeting with Betis last week, Kanouté was rested for the goalless draw against Real Sociedad at the weekend.
Now the two clubs meet again in the league as a resurgent verdiblanco outfit look to dent their arch rivals quest for the league title.
The former West Ham United and Tottenham Hotspur striker has become a key component in the Spanish club's push for silverware, both domestically and in Europe.
After stating at the start of the current campaign that he was not a goalscorer and saw himself as a provider, Kanouté has now beaten his own personal best tally.
In his first season at Sevilla he scored just six league goals, and has never scored more than 11 in one season, but he already has 16 to his name this term.
Goal.com - Kanouté Doubtful For Derby Game